Biomedical Engineering Interest Group

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Joint ISR/IMM seminar in Biomedical Engineering

Edíficio Egas Moniz, Hospital de Santa Maria Dia ? de Abril de 2008 às ?? horas

First Talk: José Rino (IMM) (joserino@gmail.com)

Title:

Abstract:

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Second Talk: João Sanches (ISR) (jmrs@isr.ist.utl.pt)

Title: Sequence Denoising of Fluorescence Confocal Microscopy Images with Anisotropic Filtering.

Abstract: Fluorescence Confocal Microscopy (FCM) is one of the most important tools in biomedicine research. In fact, it makes possible to accurately study the dynamic processes occurring inside the cell and its nucleus by following the motion of fluorescent molecules along the time. Due to the small amount of acquired radiation and the huge optical and electronics amplification, the FCM images are usually corrupted by a severe type of Poisson noise. This noise may be even more damaging when very low intensity incident radiation is used to avoid phototoxicity. In this talk a Bayesian algorithm is described to remove the Poisson multiplicative noise corrupting the FCM images. The observations are organized in a 3D tensor where each plane is one of the images acquired along the time of a cell using the Fluorescence Loss In Photobleaching (FLIP) technique. The method removes simultaneously the noise by considering different spatial and temporal correlations. This is done by using an anisotropic 3D filter that may be separately tuned in space and time dimensions.

Biological Imaging

Karyotyping

Biomedical signal processing